Cardiovascular risk factors mediating the protective effect of education on cervical spondylosis risk.

ABSTRACT: The causal association between education and cervical spondylosis may be mediated partly through risk factors of cardiovascular disease. The identification of the protective effect of education and the evaluation of risk factors will help to optimize disease prevention at both clinical and public health levels. In this study, we applied several different Mendelian randomization (MR) methods to identify which cardiovascular factors underlie the clustering of cervical spondylosis with cardiovascular disease, and the degree to which these mediate an effect of education. Univariable MR analyses provided evidence supporting a protective effect of genetically predicted education on cervical spondylosis risk, and MVMR further identified the direct effect of education level. Our results also provi

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9845322 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature