Modulations of the neuronal trafficking of tissue-type plasminogen activator (tPA) influences glutamate release.

ABSTRACT: The discovery of the neuronal expression of the serine protease tissue-type plasminogen activator (tPA) has opened new avenues of research, with important implications in the physiopathology of the central nervous system. For example, the interaction of tPA with synaptic receptors (NMDAR, LRP1, Annexin II, and EGFR) and its role in the maturation of BDNF have been reported to influence synaptic plasticity and neuronal survival. However, the mechanisms regulating the neuronal trafficking of tPA are unknown. Here, using high-resolution live cell imaging and a panel of innovative genetic approaches, we first unmasked the dynamic characteristics of the dendritic and axonal trafficking of tPA-containing vesicles under different paradigms of neuronal activation or inhibition. We then report a co

SUBMITTER: Varangot A 

PROVIDER: S-EPMC9845363 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature