Genetic heritability as a tool to evaluate the precision of 24-hour recall dietary questionnaire variables in UK Biobank.

ABSTRACT: A variety of statistical approaches in nutritional epidemiology have been developed to enhance the precision of dietary variables derived from longitudinal questionnaires. Correlation with biomarkers is often used to assess the relative validity of these different approaches, however, validated biomarkers do not always exist and are costly and laborious to collect. We present a novel high-throughput approach which utilizes the modest but importantly non-zero influence of genetic variation on variation in dietary intake to compare different statistical transformations of dietary variables. Specifically, we compare the heritability of crude averages with Empirical Bayes weighted averages for 302 correlated dietary variables from multiple 24-hour recall questionnaires in 177 K individuals in

SUBMITTER: Cole JB 

PROVIDER: S-EPMC9845390 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature