Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages.

ABSTRACT: It is well established that infection with Leishmania alters the host cell's transcriptome. Since mammalian cells have multiple mechanisms to control gene expression, different molecules, such as noncoding RNAs, can be involved in this process. MicroRNAs have been extensively studied upon Leishmania infection, but whether long noncoding RNAs (lncRNAs) are also altered in macrophages is still unexplored. We performed RNA-seq from THP-1-derived macrophages infected with Leishmania amazonensis (La), L. braziliensis (Lb), and L. infantum (Li), investigating a previously unappreciated fraction of macrophage transcriptome. We found that more than 24% of the total annotated transcripts and 30% of differentially expressed (DE) R

SUBMITTER: Fernandes JCR 

PROVIDER: S-EPMC9845402 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature