Inference of gene-environment interaction from heterogeneous case-parent trios.

ABSTRACT: Introduction: In genetic epidemiology, log-linear models of population risk may be used to study the effect of genotypes and exposures on the relative risk of a disease. Such models may also include gene-environment interaction terms that allow the genotypes to modify the effect of the exposure, or equivalently, the exposure to modify the effect of genotypes on the relative risk. When a measured test locus is in linkage disequilibrium with an unmeasured causal locus, exposure-related genetic structure in the population can lead to spurious gene-environment interaction; that is, to apparent gene-environment interaction at the test locus in the absence of true gene-environment interaction at the causal locus. Exposure-related genetic structure occurs when the distributions of exposure

SUBMITTER: Ratnasekera P 

PROVIDER: S-EPMC9845406 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature