Odor Enrichment Attenuates the Anesthesia/Surgery-induced Cognitive Impairment.

ABSTRACT:

Objective

To determine the association between olfactory function and cognition in patients and rodents.

Background

Perioperative neurocognitive disorders include delayed neurocognitive recovery (dNCR). The contribution of olfactory function to dNCR remains undetermined. It is unknown whether odor enrichment could mitigate dNCR.

Methods

We performed a prospective observational cohort study to determine potential association between olfactory impairment and dNCR in patients. We assessed the effects of anesthesia/surgery on olfactory and cognitive function in mice using the block test and Barnes maze. We measured interleukin-6 (IL-6), olfactory mature protein, growth-associated protein 43, mature and premature olfactory neurons, postsynaptic density 95, and synaptophysi

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9845427 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature