The role of radiotherapy in HER2+ early-stage breast cancer patients after breast-conserving surgery.

ABSTRACT:

Background

Due to radioresistance, some HER2+ patients may gain limited benefit from radiotherapy (RT) after breast-conserving surgery (BCS). This study aimed to develop an individualized nomogram to identify early-stage HER2+ patients who could omit RT after BCS.

Methods

The data of HER2+ patients with T0-2N0M0 breast cancer after BCS between 2010 and 2015 were extracted from Surveillance, Epidemiology, and End Results (SEER). Based on the independent prognostic factors determined by the Cox analysis in patients without RT after propensity score matching (PSM), the nomogram and risk stratification model were constructed, and then the prognosis of patients with and without RT was compared in each stratified group.

Results

A total of 10799 early-stage HER2+ patients af

SUBMITTER: Yang H 

PROVIDER: S-EPMC9845557 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature