Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide.

ABSTRACT: The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.

SUBMITTER: Santos AS 

PROVIDER: S-EPMC9845755 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature