Comparative efficacy of transcranial magnetic stimulation on different targets in Parkinson's disease: A Bayesian network meta-analysis.

ABSTRACT:

Background/objective

The efficacy of transcranial magnetic stimulation (TMS) on Parkinson's disease (PD) varies across the stimulation targets. This study aims to estimate the effect of different TMS targets on motor symptoms in PD.

Methods

A Bayesian hierarchical model was built to assess the effects across different TMS targets, and the rank probabilities and the surface under the cumulative ranking curve (SUCRA) values were calculated to determine the ranks of each target. The primary outcome was the Unified Parkinson's Disease Rating Scale part-III. Inconsistency between direct and indirect comparisons was assessed using the node-splitting method.

Results

Thirty-six trials with 1,122 subjects were included for analysis. The pair-wise meta-analysis results showed t

SUBMITTER: Dong K 

PROVIDER: S-EPMC9845788 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature