Analysis of AVPR1A, thermal and pressure pain thresholds, and stress in sickle cell disease.

ABSTRACT:

Aim

In patients with sickle cell disease (SCD), negative physical and emotional experiences result from intense chronic and acute pain episodes, but factors underlying these, and their interactions, are not well understood. The arginine vasopressin receptor 1a gene (AVPR1A) single nucleotide polymorphism rs10877969 has been previously associated with aspects of acute pain and stress related pain. In this study, we tested for associations between this SNP, thermal and pressure pain thresholds, clinical pain, and stress in people with SCD.

Methods

150 adults enrolled with SCD completed pain intensity measures (Average Pain Intensity, API) and the Perceived Stress Questionnaire (PSQ). Thermal and pressure pain threshold data were available from quantitative sensory testi

SUBMITTER: Powell-Roach KL 

PROVIDER: S-EPMC9845903 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature