The proteomic landscape shows oncologic relevance in cystitis glandularis.

ABSTRACT:

Background

The relationship between cystitis glandularis (CG) and bladder malignancy remains unclear.

Methods

We identified the oncologic significance of CG at the molecular level using liquid chromatography-tandem mass spectrometry-based proteomic analysis of 10 CG, 12 urothelial carcinoma (UC), and nine normal urothelium (NU) specimens. Differentially expressed proteins (DEPs) were identified based on an analysis of variance false discovery rate < 0.05, and their functional enrichment was analyzed using a network model, Gene Set Enrichment Analysis, and Gene Ontology annotation.

Results

We identified 9,890 proteins across all samples and 1,139 DEPs among the three entities. A substantial number of DEPs overlapped in CG/NU, distinct from UC. Interestingly, we found t

SUBMITTER: Kim JY 

PROVIDER: S-EPMC9846008 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature