Microglial heterogeneity and complement component 3 elimination within emerging multisensory midbrain compartments during an early critical period.

ABSTRACT: The lateral cortex of the inferior colliculus (LCIC) is a midbrain shell region that receives multimodal inputs that target discrete zones of its compartmental (modular-matrix) framework. This arrangement emerges perinatally in mice (postnatal day, P0-P12) as somatosensory and auditory inputs segregate into their respective modular and matrix terminal patterns. Microglial cells (MGCs) perform a variety of critical functions in the developing brain, among them identifying areas of active circuit assembly and selectively pruning exuberant or underutilized connections. Recent evidence in other brain structures suggest considerable MGC heterogeneity across the lifespan, particularly during established developmental critical periods. The present study examines the potential involvement of class

SUBMITTER: Carroll JB 

PROVIDER: S-EPMC9846048 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature