Development and validation of a prognostic prediction model for iron metabolism-related genes in patients with pancreatic adenocarcinoma.

ABSTRACT: Background: Pancreatic adenocarcinoma (PAAD) is one of the most aggressive tumors of the digestive tract, with low surgical resection rate and insensitivity to radiotherapy and chemotherapy. Existing evidence suggests that regulation of ferroptosis can induce PAAD cell death, inhibit tumor growth, and may synergistically improve the sensitivity of other antitumor drugs. However, there is little of systematic research on iron metabolism-related genes in PAAD. In this study, a risk-score system of PAAD iron metabolism-related genes was designed and tested, and verified to be robust. Materials and Methods: The TCGA database was used to download 177 PAAD patients' message RNA (mRNA) expression profiles and clinical characteristics. By identifying dysregulated iron metabolism-rela

SUBMITTER: Wei W 

PROVIDER: S-EPMC9846079 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature