Enhanced phosphatidylserine exposure and erythropoiesis in Babesia microti-infected mice.

ABSTRACT:

Introduction

Babesia microti (B. microti) is the dominant species responsible for human babesiosis, which is associated with severe hemolytic anemia and splenomegaly because it infects mammalian erythrocytes. The actual prevalence of B. microti is thought to have been substantially underestimated.

Methods

In this study, Bagg's albino/c (BALB/c) mice were intraperitoneally injected with B. microti-infected erythrocytes, and parasitemia was subsequently measured by calculating the proportion of infected erythrocytes. The ultrastructure of infected erythrocytes was observed using scanning and transmission electron microscopes. Quantifying phosphatidylserine (PS) exposure, oxidative stress, intracellular Ca²⁺, and erythropoiesis of erythrocytes we

SUBMITTER: Song P 

PROVIDER: S-EPMC9846230 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature