Load-dependent functional connectivity deficits during visual working memory in first-episode psychosis.

ABSTRACT:

Introduction

Aberrant network connectivity is a core deficit in schizophrenia and may underlie many of its associated cognitive deficits. Previous work in first-episode schizophrenia spectrum illness (FESz) suggests preservation of working memory network function during low-load conditions with dysfunction emerging as task complexity increases. This study assessed visual network connectivity and its contribution to load-dependent working memory impairments.

Methods

Magnetoencephalography was recorded from 35 FESz and 28 matched controls (HC) during a lateralized change detection task. Impaired alpha desynchronization was previously identified within bilateral dorsal occipital (Occ) regions. Here, whole-brain alpha-band connectivity was examined using phase-locking (PLV) and

SUBMITTER: Sklar AL 

PROVIDER: S-EPMC9846371 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature