Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy.

ABSTRACT:

Background

Oxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure is reported to generate ROS in laboratory settings, and is linked to adverse birth outcomes globally. However, to our knowledge, the relationship between PFAS and oxidative stress has not been examined in the context of human pregnancy.

Objective

To investigate the associations between prenatal PFAS exposure and oxidative stress biomarkers among pregnant people.

Methods

Our analytic sample included 428 participants enrolled in the Illinois Kids Development Study and Chemicals In Our Bodies prospective birth cohorts between 2014 and 2019. Twelve PFAS were measured in second trimester serum. We focused

SUBMITTER: Taibl KR 

PROVIDER: S-EPMC9846434 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature