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A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues.

ABSTRACT: We developed a novel one-pot strategy for synthesizing biologically important 1,2,4-triazole motifs from easily accessible 4-hydroxy phenylacetic acid, formamidine hydrochloride and hydrazine derivatives under mild conditions. This strategy enabled us to synthesize the natural penipanoid A and its analogues in one step.

SUBMITTER: Reddy AS

PROVIDER: S-EPMC9846445 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues.

Reddy A Satyanarayana AS Reddy V Krishna VK Rao G Nageswara GN Basavaiah K K Nagulapalli Venkata Kalyan C KC

RSC advances 20230118 4

We developed a novel one-pot strategy for synthesizing biologically important 1,2,4-triazole motifs from easily accessible 4-hydroxy phenylacetic acid, formamidine hydrochloride and hydrazine derivatives under mild conditions. This strategy enabled us to synthesize the natural penipanoid A and its analogues in one step. ...[more]

PMID: 36741146

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