Entorhinal-hippocampal interactions lead to globally coherent representations of space.

ABSTRACT: The firing maps of grid cells in the entorhinal cortex are thought to provide an efficient metric system capable of supporting spatial inference in all environments. However, whether spatial representations of grid cells are determined by local environment cues or are organized into globally coherent patterns remains undetermined. We propose a navigation model containing a path integration system in the entorhinal cortex and a cognitive map system in the hippocampus. In the path integration system, grid cell network and head direction (HD) cell network integrate movement and visual information, and form attractor states to represent the positions and head directions of the animal. In the cognitive map system, a topological map is constructed capturing the attractor states of the path integ

SUBMITTER: Zeng T 

PROVIDER: S-EPMC9846457 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature