A little goes a long way: Neurobiological effects of low intensity rTMS and implications for mechanisms of rTMS.

ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) is a widespread technique in neuroscience and medicine, however its mechanisms are not well known. In this review, we consider intensity as a key therapeutic parameter of rTMS, and review the studies that have examined the biological effects of rTMS using magnetic fields that are orders of magnitude lower that those currently used in the clinic. We discuss how extensive characterisation of "low intensity" rTMS has set the stage for translation of new rTMS parameters from a mechanistic evidence base, with potential for innovative and effective therapeutic applications. Low-intensity rTMS demonstrates neurobiological effects across healthy and disease models, which include depression, injury and regeneration, abnormal circuit organisation,

SUBMITTER: Moretti J 

PROVIDER: S-EPMC9846462 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature