Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19.

ABSTRACT:

Introduction

After more than two years the Coronavirus disease-19 (COVID-19) pandemic continues to burden healthcare systems and economies worldwide, and it is evident that the effects on the immune system can persist for months post-infection. The activity of myeloid cells such as monocytes and dendritic cells (DC) is essential for correct mobilization of the innate and adaptive responses to a pathogen. Impaired levels and responses of monocytes and DC to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is likely to be a driving force behind the immune dysregulation that characterizes severe COVID-19.

Methods

Here, we followed a cohort of COVID-19 patients hospitalized during the early waves of the pandemic for 6-7 months. The levels and phenotypes of circulatin

SUBMITTER: Hopkins FR 

PROVIDER: S-EPMC9846644 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature