Evidence for Implementation: HIV/HCV Coinfection and Pregnancy.

ABSTRACT:

Purpose of review

In the context of the opioid epidemic, hepatitis C virus (HCV) infection prevalence is increasing among women of reproductive age. Pregnant people with HIV/HCV coinfection may be at increased risk of adverse pregnancy and neonatal outcomes, although research in this key population is lacking.

Recent findings

Treatment with directly acting antivirals (DAAs) has transformed the clinical care for most patients with HCV. However, pregnant people were excluded from trials of these medications. A recent phase I study has shown promise with excellent safety profile for ledipasvir-sofosbuvir; demonstrating no episodes of perinatal transmission, 100% sustained virologic response, and no safety concerns. Pregnancy represents a time of maximal interaction with the hea

SUBMITTER: Curtis MR 

PROVIDER: S-EPMC9846668 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature