Not all phenotypes are created equal: covariates of success in e-phenotype specification.

ABSTRACT:

Background

Electronic (e)-phenotype specification by noninformaticist investigators remains a challenge. Although validation of each patient returned by e-phenotype could ensure accuracy of cohort representation, this approach is not practical. Understanding the factors leading to successful e-phenotype specification may reveal generalizable strategies leading to better results.

Materials and methods

Noninformaticist experts (n = 21) were recruited to produce expert-mediated e-phenotypes using i2b2 assisted by a honest data-broker and a project coordinator. Patient- and visit-sets were reidentified and a random sample of 20 charts matching each e-phenotype was returned to experts for chart-validation. Attributes of the queries and expert characteristics were captured and rel

SUBMITTER: Hamidi B 

PROVIDER: S-EPMC9846689 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature