Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
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ABSTRACT:
SUBMITTER: Troisi R
PROVIDER: S-EPMC9846693 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
Troisi Romualdo R Galardo Francesco F Ferraro Giarita G Sica Filomena F Merlino Antonello A
Inorganic chemistry 20230105 2
The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation. ...[more]
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