Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.

ABSTRACT:

Objective

To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD).

Design

Pooled analysis.

Data sources

A consortium of 19 studies from 12 countries identified up to May 2020.

Study selection

Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate.

Data extraction and synthesis

Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using in

SUBMITTER: Ong KL 

PROVIDER: S-EPMC9846698 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature