CSF rhinorrhoea after endonasal intervention to the skull base (CRANIAL): A multicentre prospective observational study

ABSTRACT:

Objective

Despite progress in endonasal skull-base neurosurgery, cerebrospinal fluid (CSF) rhinorrhoea remains common and significant. The CRANIAL study sought to determine 1) the scope of skull-base repair methods used, and 2) corresponding rates of postoperative CSF rhinorrhoea in the endonasal transsphenoidal approach (TSA) and the expanded endonasal approach (EEA) for skull-base tumors.

Methods

A prospective observational cohort study of 30 centres performing endonasal skull-base neurosurgery in the UK and Ireland (representing 91% of adult units). Patients were identified for 6 months and followed up for 6 months. Data collection and analysis was guided by our published protocol and pilot studies. Descriptive statistics, univariate and multivariable logistic regressi

SUBMITTER:  

PROVIDER: S-EPMC9846732 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature