MHC Class I on murine hematopoietic APC selects Type A IEL precursors in the thymus.

ABSTRACT: TCRαβ⁺ CD8α⁺ CD8β^- intestinal intraepithelial lymphocytes (CD8αα IEL) are gut T cells that maintain barrier surface homeostasis. Most CD8αα IEL are derived from thymic precursors (IELp) through a mechanism referred to as clonal diversion. In this model, self-reactive thymocytes undergo deletion in the presence of CD28 costimulation, but in its absence undergo diversion to the IEL fate. While previous reports showed that IELp were largely β2m dependent, the APC that drive the development of these cells are poorly defined. We found that both CD80 and CD86 restrain IELp development, and conventional DCs play a prominent role. We sought to define a CD80/86 negative, MHCI positive APC that supports the development to the IEL lineage. Chimera studies showed that

SUBMITTER: Lee ST 

PROVIDER: S-EPMC9846822 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature