Physiological mechanism and spatial distribution of increased alveolar dead-space in early ARDS: An experimental study.

ABSTRACT:

Background

We aimed to investigate the physiological mechanism and spatial distribution of increased physiological dead-space, an early marker of ARDS mortality, in the initial stages of ARDS. We hypothesized that: increased dead-space results from the spatial redistribution of pulmonary perfusion, not ventilation; such redistribution is not related to thromboembolism (ie, areas with perfusion = 0 and infinite ventilation-perfusion ratio, V ˙ / Q ˙ ), but rather to moderate shifts of perfusion increasing V ˙ / Q ˙ in non-dependent regions.

Methods

Five healthy anesthetized sheep received protective ventilation for 20 hours, while endotoxin was continuously infused. Maps of voxel-level lung ventilation, perfusion, V ˙ / Q ˙ , CO₂ partial pressures, and alv

SUBMITTER: Beda A 

PROVIDER: S-EPMC9846860 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature