Susceptible windows of exposure to fine particulate matter and fetal growth trajectories in the Spanish INMA (INfancia y Medio Ambiente) birth cohort.

ABSTRACT: While prior studies report associations between fine particulate matter (PM_2.5) exposure and fetal growth, few have explored temporally refined susceptible windows of exposure. We included 2328 women from the Spanish INMA Project from 2003 to 2008. Longitudinal growth curves were constructed for each fetus using ultrasounds from 12, 20, and 34 gestational weeks. Z-scores representing growth trajectories of biparietal diameter, femur length, abdominal circumference (AC), and estimated fetal weight (EFW) during early (0-12 weeks), mid- (12-20 weeks), and late (20-34 weeks) pregnancy were calculated. A spatio-temporal random forest model with back-extrapolation provided weekly PM_2.5 exposure estimates for each woman during her pregnancy. Distributed lag non-linear models

SUBMITTER: Chen WJ 

PROVIDER: S-EPMC9847009 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature