14-3-3η protein is associated with disease activity and osteoporosis in patients with rheumatoid arthritis.

ABSTRACT:

Introduction

This study was designed to explore the potential association of serum 14-3-3η protein level with disease activity and bone mineral density (BMD) in Egyptian patients with rheumatoid arthritis (RA). Patients were recruited from the outpatient clinic at Mansoura University Hospital.

Material and methods

One hundred eighty-eight patients with RA and 192 matched controls were enrolled. The rheumatoid arthritis activity parameters were evaluated in RA patients. Bone mineral density was measured. Serum levels of 14-3-3η protein and IL-6 were estimated for all participants by enzyme-linked immunosorbent assays (ELISA).

Results

Rheumatoid arthritis patients had a significantly higher median serum 14-3-3η protein level compared to matched controls (p ≤ 0.05

SUBMITTER: Adel Y 

PROVIDER: S-EPMC9847109 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature