Effect of marker-free transgenic Chlamydomonas on the control of Aedes mosquito population and on plankton.

ABSTRACT:

Background

More than half of the world's population suffers from epidemic diseases that are spread by mosquitoes. The primary strategy used to stop the spread of mosquito-borne diseases is vector control. Interference RNA (RNAi) is a powerful tool for controlling insect populations and may be less susceptible to insect resistance than other strategies. However, public concerns have been raised because of the transfer of antibiotic resistance marker genes to environmental microorganisms after integration into the recipient genome, thus allowing the pathogen to acquire resistance. Therefore, in the present study, we modified the 3-hydroxykynurenine transaminase (3hkt) and hormone receptor 3 (hr3) RNAi vectors to remove antibiotic resistance marker genes and retain the expression cass

SUBMITTER: Fei X 

PROVIDER: S-EPMC9847121 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature