Continuous dynamic identification of key genes and molecular signaling pathways of periosteum in guided bone self-generation in swine model.

ABSTRACT:

Background

Guided bone self-generation with periosteum-preserved has successfully regenerated mandibular, temporomandibular and interphalangeal joint. The aim of this study was to investigate the dynamic changes of gene expression of periosteum which was involved in the guided bone self-generation.

Methods

Rib defects of critical size were created in mature swine with periosteum-preserved. The periosteum was sutured into a sealed sheath that closed the bone defect. The periosteum of trauma and control sites were harvested at postoperative 9 time points, and total RNA was extracted. Microarray analysis was conducted to identify the differences in the transcriptome of different time points between two groups.

Results

The differentially expressed genes (DEGs) between con

SUBMITTER: Yu BF 

PROVIDER: S-EPMC9847205 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature