Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis.

ABSTRACT:

Background

Intracranial pressure waveform morphology reflects compliance, which can be decreased by ventriculitis. We investigated whether morphologic analysis of intracranial pressure dynamics predicts the onset of ventriculitis.

Methods

Ventriculitis was defined as culture or Gram stain positive cerebrospinal fluid, warranting treatment. We developed a pipeline to automatically isolate segments of intracranial pressure waveforms from extraventricular catheters, extract dominant pulses, and obtain morphologically similar groupings. We used a previously validated clinician-supervised active learning paradigm to identify metaclusters of triphasic, single-peak, or artifactual peaks. Metacluster distributions were concatenated with temperature and routine blood laboratory value

SUBMITTER: Megjhani M 

PROVIDER: S-EPMC9847350 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature