In silico detection and characterization of novel virulence proteins of the emerging poultry pathogen Gallibacterium anatis.

ABSTRACT: The pathogen Gallibacterium anatis has caused heavy economic losses for commercial poultry farms around the world. However, despite its importance, the functions of its hypothetical proteins (HPs) have been poorly characterized. The present study analyzed the functions and structures of HPs obtained from Gallibacterium anatis (NCTC11413) using various bioinformatics tools. Initially, all the functions of HPs were predicted using the VICMpred tool, and the physicochemical properties of the identified virulence proteins were then analyzed using Expasy's ProtParam server. A virulence protein (WP_013745346.1) that can act as a potential drug target was further analyzed for its secondary structure, followed by homology modeling and three-dimensional (3D) structure determination using the Swiss-

SUBMITTER: Rajapaksha LGTG 

PROVIDER: S-EPMC9847380 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature