Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis.

ABSTRACT:

Aims

Viral myocarditis (VM) is an inflammatory pathology of the myocardium triggered by a viral infection that may cause sudden death or heart failure (HF), especially in the younger population. Current treatments only stabilize and improve cardiac function without resolving the underlying inflammatory cause. The factors that induce VM to progress to HF are still uncertain, but neutrophils have been increasingly associated with the negative evolution of cardiac pathologies. The present study investigates the contribution of neutrophils to VM disease progression in different ways.

Methods and results

In a coxsackievirus B3- (CVB3) induced mouse model of VM, neutrophils and neutrophil extracellular traps (NETs) were prominent in the acute phase of VM as revealed by enzyme-link

SUBMITTER: Carai P 

PROVIDER: S-EPMC9847559 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature