Working status and risk of Alzheimer's disease: A Mendelian randomization study.

ABSTRACT:

Background

Alzheimer's disease (AD) has become a common illness affecting the elderly, adding to society's social and financial burden. We used two-sample Mendelian randomization (MR) in this study to determine the association between working status and AD.

Methods

We performed a two-sample MR analysis. The genetic associations were derived from the UK Biobank (n = 263,615) and the International Genomics of Alzheimer's Project (n = 63,926). Inverse variance weighted (IVW), MR-Egger, and weighted median were used in the MR analysis. The funnel plot, Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis were used in sensitivity analyses. Further risk factor analyses were carried out to look into the potential mediators.

Results

Jobs involve heavy manual

SUBMITTER: Zhao J 

PROVIDER: S-EPMC9847601 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature