Amyloid-β PET in Alzheimer's disease: A systematic review and Bayesian meta-analysis.

ABSTRACT:

Background

In recent years, longitudinal studies of Alzheimer's disease (AD) have been successively concluded. Our aim is to determine the efficacy of amyloid-β (Aβ) PET in diagnosing AD and early prediction of mild cognitive impairment (MCI) converting to AD. By pooling studies from different centers to explore in-depth whether diagnostic performance varies by population type, radiotracer type, and diagnostic approach, thus providing a more comprehensive theoretical basis for the subsequent widespread application of Aβ PET in the clinical setting.

Methods

Relevant studies were searched through PubMed. The pooled sensitivities, specificities, DOR, and the summary ROC curve were obtained based on a Bayesian random-effects model.

Results

Forty-eight studies, including 5

SUBMITTER: Ruan D 

PROVIDER: S-EPMC9847612 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature