Alcohol use is associated with affective and interoceptive network alterations in bipolar disorder.

ABSTRACT:

Introduction

Alcohol use in bipolar disorder (BD) is associated with mood lability and negative illness trajectory, while also impacting functional networks related to emotion, cognition, and introspection. The adverse impact of alcohol use in BD may be explained by its additive effects on these networks, thereby contributing to a poorer clinical outcome.

Methods

Forty BD-I (DSM-IV-TR) and 46 psychiatrically healthy controls underwent T1 and resting state functional MRI scanning and the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) to assess alcohol use. Functional images were decomposed using spatial independent component analysis into 14 resting state networks (RSN), which were examined for effect of alcohol use and diagnosis-by-alcohol use accounting for

SUBMITTER: Martyn FM 

PROVIDER: S-EPMC9847622 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature