The impact of age on outcomes of breast cancer in different hormone receptor and HER2 groups.

ABSTRACT:

Objective

The aim of the current study was to explore the association between age and outcomes in breast cancer.

Methods

Patients during 2010-2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and breast cancer-specific death (BCSD) were taken as endpoints. The restrict cubic spline graph (RCS) was used to explore the relationship between age and outcomes in patients, and the cumulative incidence of BCSD and non-BCSD was calculated using the Gray method. Age-specific gene expression profiles were studied using RNA sequence data from the Cancer Genome Atlas (TCGA) database to explore whether there were young age-related gene or gene sets.

Results

A total of 142,755 patients with breast cancer were included.

SUBMITTER: Zheng H 

PROVIDER: S-EPMC9847906 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature