Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.

ABSTRACT: Compensation is a defining principle of a true circadian clock, where its approximately 24-hour period length is relatively unchanged across environmental conditions. Known compensation effectors directly regulate core clock factors to buffer the oscillator's period length from variables in the environment. Temperature Compensation mechanisms have been experimentally addressed across circadian model systems, but much less is known about the related process of Nutritional Compensation, where circadian period length is maintained across physiologically relevant nutrient levels. Using the filamentous fungus Neurospora crassa, we performed a genetic screen under glucose and amino acid starvation conditions to identify new regulators of Nutritional Compensation. Our screen uncovered 16 novel mu

SUBMITTER: Kelliher CM 

PROVIDER: S-EPMC9848017 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature