Phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections (PRICE-2): study protocol for a phase 3 randomized controlled trial.

ABSTRACT:

Introduction

Blood loss and red blood cell (RBC) transfusion in liver surgery are areas of concern for surgeons, anesthesiologists, and patients alike. While various methods are employed to reduce surgical blood loss, the evidence base surrounding each intervention is limited. Hypovolemic phlebotomy, the removal of whole blood from the patient without volume replacement during liver transection, has been strongly associated with decreased bleeding and RBC transfusion in observational studies. This trial aims to investigate whether hypovolemic phlebotomy is superior to usual care in reducing RBC transfusions in liver resection.

Methods

This study is a double-blind multicenter randomized controlled trial. Adult patients undergoing major hepatic resections for any indication wi

SUBMITTER: Martel G 

PROVIDER: S-EPMC9848035 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature