PTMint database of experimentally verified PTM regulation on protein-protein interaction.

ABSTRACT:

Motivation

Post-translational modification (PTM) is an important biochemical process. which includes six most well-studied types: phosphorylation, acetylation, methylation, sumoylation, ubiquitylation and glycosylation. PTM is involved in various cell signaling pathways and biological processes. Abnormal PTM status is closely associated with severe diseases (such as cancer and neurologic diseases) by regulating protein functions, such as protein-protein interactions (PPIs). A set of databases was constructed separately for PTM sites and PPI; however, the resource of regulation for PTM on PPI is still unsolved.

Results

Here, we firstly constructed a public accessible database of PTMint (PTMs that are associated with PPIs) (https://ptmint.sjtu.edu.cn/) that contains manually c

SUBMITTER: Hong X 

PROVIDER: S-EPMC9848059 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature