Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes.

ABSTRACT: Infections of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have triggered a global pandemic with millions of deaths worldwide. Herein, the synthesis of functionalized Re(i) tricarbonyl complexes as inhibitors of the SARS-CoV-2 main protease, also referred to as the 3-chymotrypsin-like protease (3CL^pro), is presented. The metal complexes were found to inhibit the activity of the enzyme with IC₅₀ values in the low micromolar range. Mass spectrometry revealed that the metal complexes formed a coordinate covalent bond with the enzyme. Chiral separation of the enantiomers of the lead compound showed that one enantiomer was significantly more active than the other, consistent with specific binding and much like that observed for conventional organic smal

SUBMITTER: Karges J 

PROVIDER: S-EPMC9848156 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature