The effect of low-intensity extracorporeal shockwave therapy in an obesity-associated erectile dysfunction rat model.

ABSTRACT:

Objectives

To investigate the feasibility of the Zucker fatty (ZF) rat as a model for research in to obesity-associated erectile dysfunction (OAED) and to determine the effect of low-intensity extracorporeal shockwave therapy (Li-ESWT) on penile tissue and function in these rats.

Materials and methods

Eight new-born male Zucker lean (ZL group) rats (ZUC-Lepr^fa 186) and 16 new-born male ZF rats (ZUC-Lepr^fa 185) were injected with 5-ethynyl-2'-deoxyuridine (EdU) at birth to identify and monitor endogenous stem cells. Insulin tolerance testing was performed at 10 weeks of age. Beginning at 12 weeks of age, eight ZF rats were kept as controls, and the remaining eight ZF rats were treated with Li-ESWT (0.02 mJ/mm² , 3 Hz, 500 pulses; ZF + SW group

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC9848222 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature