Profiling the alterations of serum proteome in dairy cows with retained placenta using high-throughput tandem mass tags quantitative approach.

ABSTRACT:

Background

Retained placenta (RP), a quite common disorder in dairy cows, shows a high negative impact on their health status and milk production.

Aim

To investigate the difference in the serum proteome between the cows with RP and the physiologic puerperium (PP).

Material & methods

Analysis of serum samples from nine cows with RP and six with PP using high-resolution liquid chromatography-tandem mass spectrometry approach. The proteins differing in the relative abundance between the PP and RP groups were classified using the Protein Analysis Through Evolutionary Relationship tool. For the pathway enrichment analysis, the REACTOME tool, with the human genome as the background, was employed. The criterion for significance was the false discovery rate corrected P-value

SUBMITTER: Beletic A 

PROVIDER: S-EPMC9848263 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature