Clinical value of the renal pathologic scoring system in complement-mediated thrombotic microangiopathy.

ABSTRACT:

Objectives

This study was initiated to establish a renal thrombotic microangiopathy (TMA) scoring system based on clinical needs and investigate its predictive value for patients' long-term outcomes.

Methods

Kidney biopsy-proven Complement-mediated TMA (C-TMA) patients from January 2000 to December 2017 in Peking University First Hospital were retrospectively studied. Both acute and chronic TMA-related lesions, including 15 pathologic indices, were semiquantitatively scored. The interobserver and intraobserver reproducibility and correlation between the pathologic indices and clinical parameters were analyzed. Furthermore, the patients were divided into 2 groups by dialysis use at baseline, and the association of these pathologic indices with their prognostic outcomes was as

SUBMITTER: Chen FF 

PROVIDER: S-EPMC9848373 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature