A new perspective on semen quality of aged male: The characteristics of metabolomics and proteomics.

ABSTRACT:

Background

Semen quality is negatively correlated with male age and is mainly quantified by a routine semen analysis, which is descriptive and inconclusive. Sperm proteins or semen metabolites are used as the intermediate or end-products, reflecting changes in semen quality, and hold much promise as a new biomarker to predict fertility in advanced-aged males.

Objectives

In this study, we sought to assess whether the semen metabolome and proteome of aged males can affect semen quality and serve as biomarkers for predicting semen quality.

Materials and methods

We retrospectively analyzed 12825 males that underwent semen routine analysis to understand the age-dependent changes in sperm quality. To identify the difference between aged and young adults, metabolomics (n=60)

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9848653 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature