Synaptic gradients transform object location to action.

ABSTRACT: To survive, animals must convert sensory information into appropriate behaviours^1,2. Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses^3-5. How circuitry converts object location in retinal coordinates to movement direction in body coordinates remains largely unknown. Here we show through behaviour, physiology, anatomy and connectomics in Drosophila that visuomotor transformation occurs by conversion of topographic maps formed by the dendrites of feature-detecting visual projection neurons (VPNs)^6,7 into synaptic weight gradients of VPN outputs onto central brain neurons. We demonstrate how this gradient motif transforms the anteroposterior location of a visual looming stimulus into the fly's directional escape.

SUBMITTER: Dombrovski M 

PROVIDER: S-EPMC9849133 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature