Consequences of Genetic Recombination on Protein Folding Stability.

ABSTRACT: Genetic recombination is a common evolutionary mechanism that produces molecular diversity. However, its consequences on protein folding stability have not attracted the same attention as in the case of point mutations. Here, we studied the effects of homologous recombination on the computationally predicted protein folding stability for several protein families, finding less detrimental effects than we previously expected. Although recombination can affect multiple protein sites, we found that the fraction of recombined proteins that are eliminated by negative selection because of insufficient stability is not significantly larger than the corresponding fraction of proteins produced by mutation events. Indeed, although recombination disrupts epistatic interactions, the mean stability of r

SUBMITTER: Del Amparo R 

PROVIDER: S-EPMC9849154 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature