Very Low Rates of Spontaneous Gene Deletions and Gene Duplications in Dictyostelium discoideum.

ABSTRACT: The study of spontaneous mutation rates has revealed a wide range of heritable point mutation rates across species, but there are comparatively few estimates for large-scale deletion and duplication rates. The handful of studies that have directly calculated spontaneous rates of deletion and duplication using mutation accumulation lines have estimated that genes are duplicated and deleted at orders of magnitude greater rates than the spontaneous point mutation rate. In our study, we tested whether spontaneous gene deletion and gene duplication rates are also high in Dictyostelium discoideum, a eukaryote with among the lowest point mutation rates (2.5 × 10^-11 per site per generation) and an AT-rich genome (GC content of 22%). We calculated mutation rates of gene deletions and dup

SUBMITTER: Gill SE 

PROVIDER: S-EPMC9849192 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature