Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes.

ABSTRACT: The perinatal period occurring immediately before and after birth is critical for cardiomyocytes because they must change rapidly to accommodate the switch from fetal to neonatal circulation after birth. This transition is a well-orchestrated process, and any perturbation leads to unhealthy cardiomyocytes and heart disease. Despite its importance, little is known about how this transition is regulated and controlled. Here, by mapping the genome-wide chromatin accessibility, transcription-centered long-range chromatin interactions and gene expression in cardiomyocytes undergoing perinatal transition, we discovered two key transcription factors, MEF2 and AP1, that are crucial for driving the phenotypic changes within the perinatal window. Thousands of dynamic regulatory elements were found i

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9849264 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature